A randomised controlled, triple-blinded, phase-3 clinical trial was conducted at the Department of Periodontology at Dr Ishrat-ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS) in Dow University of Health Sciences (DUHS), Karachi, Pakistan from September 2019 to December 2020. Helps protect teeth against cavities and promotes healthy gums (with regular brushing). A meta-analysis by Matranga et al. Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis. Lai et al. The makers of Colgate Sensitive Pro-Relief and its rival, Sensodyne Rapid Relief, have been dobbing each other into the health regulator over advertising claims that the toothpastes give users "instant" relief to pain from sensitive teeth. The formula consists of Arginine, an amino acid naturally found in saliva and also calcium from calcium carbonate. Article Colgate Sensitive Pro Relief Repair and Prevent Sensitivity Toothpaste [32] reported statistically significant improvement in mechanical stimulated DH with Pro-argin immediately after topical application relative to 8% strontium Acetate in 2016. Dentifrices were removed carefully after one minute of undisturbed application by rinsing the air lightly with an air syringe, and the subject was asked to spit. Martins C, Firmino R, Riva J, Ge L, Carrasco-Labra A, Brignardello-Petersen R, et al. Pro-Argin technology can be found in Colgate Sensitive Pro Relief Toothpaste, sold as Colgate Sensitive Instant Relief in the UK and elmex Sensitive Professional in Europe. Product Details Characteristics and Benefits Characteristics: Unique Pro-Argin TM/MC technology based on natural process of tubule occlusion 2010;21(2):428. 1). Google Scholar. reporting the instant relief from DH by 44.1% with Pro-argin on SCASS. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. No adverse events like gingival inflammation, bad taste, allergies, fluoride incompatibility, and dental or tongue stains were observed for all dentifrices. Gillam D, Talioti E. The Management of Dentine Hypersensitivity. IRB-1351/DUHS/Approval/2019/184. A total of 128 participants completed the trial. Hu et al. Schiff T, Delgado E, Zhang Y, Cummins D, DeVizio W, Mateo L. Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. These findings were similar to a previous study conducted by Schiff et al. 2019;46(12):11216. * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. Hu ML, Zheng G, Lin H, Yang M, Zhang YD, Han JM. Colgate SENSITIVE INSTANT Relief tannkrem - Colgate Professional Colgate Sensitive Pro-relief Multi Protection Toothpaste 110g For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. 2017;457:2530. Nathoo S, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR: Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride and to a control toothpaste with 1450 ppm fluoride: A three-day clinical study in New Jersey, USA. Google Scholar. Nathoo S et al. Tandkrmen har ett slipmedel som ger en mild polering och tar bort yttre flckar och fluor skyddar tnderna mot karies. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste is an everyday toothpaste. Mantzourani M, Sharma D. Dentine sensitivity: past, present and future. Lai HY, Lee S, Toh SW, Li Y, Mateo LR, Morrion BM, Zhang Y: The clinical efficacy of a new dentifrice with zinc on plaque and gingivitis. Register now and gain access to: 8 hours ECPD Product samples Patient materials Register here * For instant relief, apply directly to the sensitive tooth with finger tip and gently massage for 1 minute. Poster #3406, July 2018 IADR. Panagakos F, Schiff T, Guignon A. Dentin hypersensitivity: effective treatment with an in-office desensitizing paste containing 8% arginine and calcium carbonate. Marketing Plan For Colgate Sensitive Pro Relief - ukessays.com 2017;62(2):18691. 2020;99(5):51422. Tel: +381 (0)21 452-910, +381 (0)21 420-758. Two double-blind randomized clinical studies by Nathoo et al. Today's era of flourishing research in DH is based on incorporating bioactive ingredients in commercially available oral dentifrices that can induce deep intratubular remineralisation of dental hard tissues for permanent or long-term treatment purposes. Pashley D. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. Written consent was obtained from all participants to participate in the six-week clinical trial. These outcomes were found in concordance with the previous controlled clinical trial conducted by Patel et al. We were using the PAS version.11, two independent sample t-test with 95% confidence interval and 80% power of test, meanSD of air blast stimulus test score of test group 1.860.41 and control group 2.220.41 two weeks after baseline test score, the calculated sample size was 22 [21] which was raised to 35 including five as drop out for each group (Fig. Sealed channels protect against pain caused by hot, cold and sweet stimuli. Saba Arshad. Colgate Sensitive Instant Relief Toothpaste starts blocking sensitivity pain instantly*. and Ayad et al. However, they also suggested further comparative evaluations of two dentifrices with large sample sizes as limited scientific evidence was found in previous studies [16]. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Written informed consent was obtained with a signed agreement plan to visit for six weeks at interim efficacy intervals of day three, week two, week four, and week six. J Clin Periodontol. Colgate Sensitive Pro Relief was compared to a leading brand of desensitizing toothpaste containing stannous fluoride in a laboratory study, with confocal laser scanning microscopy and a novel imaging program used to qualify dentinal tubule occlusion. Instant relief when applied directly to the sensitive tooth with the fingertip and gently massaged for 1 minute. volume21, Articlenumber:498 (2021) Venkataramana S, Jeyaraman SK, Kothimbakkam SSK, Chellathurai BNK. For patients in the dental chair, it can be used to rapidly ease hypersensitivity pain, facilitate examinations and make dental procedures more comfortable. There was a significant (p<0.001) reduction of 45.7% with Pro-argin, 37.6% with 8% strontium acetate, 18.1% with FCPS, and 15.2% with NaF-based dentifrices relative to baseline on SCASS after one-minute application on sensitive teeth. J Clin Exp Dent. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. . Dentin hypersensitivity. Colgate-Palmolive Company 2018. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. 75 ml. Colgate Sensitive Pro-relief Enamel Repair Teeth Pain - Woolworths Then, the repeated measure was obtained after five minutes for previous pain recovery, and dentifrices were provided to the patient for self-application. Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. Colgate Sensitive Pro-relief Repair & Prevent A previously published study by Samueli et al. All rights reserved. If symptoms persist, talk to your healthcare professional. Colgate Sensitive Instant Relief Tandkrm 75 ml - Apotek Hjrtat Further, it leaves a durable, mineral-enriched layer on the exposed dentin to help protect against future dentin hypersensitivity. IADR, The Excel, United Kingdom. Pro-Argin technology provides instant* and long-lasting, Oral Care Products | Colgate Professional. 2009;20 (Spec Iss):123130. Apotekets varuid 29483 Varunummer 207000 Kategori Tandkrm, Ilningar i tnderna Varumrke 3Intervention for Group C denotes Sensodyne Rapid Action. 29,95 kr. The maximum sampling time was 15min. Colgate Sensitive Instant* Relief Enamel Repair tandkrm ger dig kliniskt bevisad lngvarig lindring** mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. who examined FCPS and Pro-argin formulations in 2018. By using this website, you agree to our In addition, participants were asked to record the overall sensitivity of their day-to-day experience on provided VAS sheets reporting pain on brushing, taking hot or cold beverages, and rinsing with tap water for the six weeks of the study. Plus it has the freshness you trust from Colgate! Layer T, Hughes N. Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity. They explored greater tubular occlusion potential and more acid resistance of Pro-argin in comparison to FCPS after subsequent seven days of application on dentinal discs [38]. Based on the outcomes of previous systematic reviews and meta-analysis, the rationale of the present study was to substantiate the claim of immediate pain relief after one-minute application in DH by non-invasive surface application of OTC dentifrices containing Pro-arginin Colgate Sensitive Pro-Relief, and 8% strontium acetate in Sensodyne Rapid Action and other objective was the comparative evaluation of the clinical efficacy of three technologies, BAG-based FCPS in BioMinR F, Pro-argin, and 8% strontium acetate at efficacy intervals of day three, week two, four and six for sustained inhibition of painful stimulus provoking DH as all three are dentinal tubular occluding dentifrices. Innehller slipmedel med ltt polerande effekt p flckar samt fluor som minskar risken fr karies. Department of Oral Biology, Dr. Ishrat-Ul-Ebad Khan Institute of Oral Health Sciences (DIKIOHS), Dow University of Health Sciences, Karachi, Pakistan, Department of Oral Biology, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan, Department of Research, School of Public Health, Dow University of Health Sciences, Karachi, Pakistan, You can also search for this author in 2020;20(3):101460. 1):8A-15A. For best performance, keep cap closed when not in use. The outcomes are in concordance with the previous studies conducted by Layer and Hughes [26], Zang and Shaw [27], and Mason et al. Get the freedom to forget about tooth sensitivity with Colgate Sensitive Pro-Relief Complete Protection Toothpaste. 1). 2009;22(Spec No. compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. Plus it has the freshness you trust from Colgate! It revealed an immediate improvement with strontium acetate more than Pro-argin on SCASS. In our study, patient compliance related to the recommended time of application and method of the application provided by doctors was controlled by subjecting multiple efficacy intervals and different methods for assessment of the change in pain scores due to DH. Trials. More robust trials with a large number of participants are recommended for furtherassessing the impact of DH on the oral health-related quality of life and the difference in the effectiveness of treatments. J Clin Dent. The benefits are backed by over a decade of clinical research, summarized as follows. Colgate Sensitive Pro-Relief Gum Therapy - Home Tester Club Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. A toothbrushing demonstration model from Nissin Company specification [PE-ORT002] was used to explain to the study participants about applying OTC dentifrices for one minute with the participant's finger. Compared to stannous fluoride/sodium fluoride and novamin/sodium fluoride. Post-hoc analysis revealed a significant reduction in DH scores in treatment arms compared to control on completing the six-week trial (p<0.05). If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. p values of<0.05 were considered as statistically significant. Colgate SENSITIVE INSTANT Relief tannkrem med Pro-Argin teknologi gir umiddelbar* og langvarig smertelindring av ising i tennene. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste with Pro-Argin Technology and Zinc. West N, Newcombe RG, Hughes N, Mason S, Maggio B, Sufi F, et al. A total of 140 participants were initially enrolled and randomised into the four treatment arms, with thirty-five in each group. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste for the daily oral care of patients with dentine hypersensitivity and gum problems. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Colgate Sensitive Pro-relief 110g - Alpro Pharmacy The first post-treatment measure of SCASS and VAS scores was obtained immediately after removing dentifrices from teeth. Colgate Sensitive Pro-Relief | ProductReview.com.au Size: 75ml (Approx.) Cookies policy. Colgate Sensitive Instant Relief Repair & Prevent Toothpaste starts blocking sensitivity pain instantly*. 2010;23(Spec No A):14A-9A. Soft tissues were isolated with cotton rolls, and adjacent teeth were isolated with cotton pellets. Poster #0742, March 2018 AADR. Dentin hypersensitivity is characterized by a short, sharp pain arising from open dentin tubules in exposed dentin in response to external stimuli, which cannot be attributed to any other defect or disease. In addition, the frequency of participants diagnosed with DH using air blast stimulus was observed as 36.8% at the time of enrolment in the six-week clinical trial that was found consistent with findings of a survey report demonstrating 36.4% frequency of DH among adults in Karachi, Pakistan [24]. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. Innehll Colgate Sensitive Instant Relief Enamel Repair r en fluortandkrm med Pro-Argin-teknologi som ger omedelbar smrtlindring vid ilningar i tnderna. J Clin Dent. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Children 6 years and younger: use a pea-sized amount for supervised tooth brushing to minimise swallowing. [28] reporting the immediate effect of 8% strontium acetate in alleviating clinical symptoms of DH with clinically and statistically significant (<0.001) measures relative to baseline [26]. Pro-Argin showed a greater reduction in DH with mean scores of (1.340.68) (4.201.70) (3.052.17) followed by strontium acetate (1.570.81) (4.651.87) (3.751.97) on SCASS and VAS for mechanical and water jet stimuli, one minute after application. Docimo R et al. (Table 1) (Fig. The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. The study's primary objective was to investigate pain relief in one minute after topical application of Pro-argin and strontium acetate on sensitive teeth in DH. Therefore, it was considered to be rejected at a p valueof 0.05. Colgate Senstive Relief vs Sensodyne Toothpaste - Lowyat.NET However, Pro-argin formulation showed 8% more improvement in clinical symptoms of DH than strontium acetate formulation one minute after application. Is Colgate better than Sensodyne - sterlingsmilesazle.com . Sensitive Instant Relief Enamel Repair - Colgate Elsevier; 2015. p. 3344. 2013;41:S317. Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. 7 Ipsos, UK Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2 weeks trial, 192 respondents, 2016. Colgate Sensitive Instant Relief Whitening Toothpaste 75ml Colgate Sensitive Instant Relief Repair & Prevent tandkrm 6 Ipsos, Romania Patient Experience Programme on Colgate SENSITIVE PRO-Relief, results collected after 2-week trial, 545 respondents, 2015. Colgate Sensitive Pro-Relief Enamel Repair contains Pro-Argin formula, helping to remineralise enamel, strengthen teeth against acid in food and drinks, plus instantly plugs channels to sensitive nerves. Though all bioactive agents have a significant treatment effect in reducing DH, there is currently no consensus on the unequivocal efficacy of any product or bioactive agent used for managing the condition due to huge variations and heterogeneity in the conduct of clinical trials on DH [6]. J Dent. All rights reserved. J Dent Probl Solut. Colgate Sensitive Pro Relief for sale | eBay Cite this article. 2015;28(1):404. FCPS showed the highest reduction in DH on SCASS and VAS for waterjet stimuli with mean scores of (0.970.68) (1.801.73) and Pro-Argin on VAS for mechanical stimuli with mean scores of (2.151.92) in six weeks. This clinical trial was approved by the Institutional Review Board of Dow University of Health Sciences (Ref: IRB-1351/DUHS/Approval/2019/184) and was registered under the protocol ID NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336) on January 30, 2020, in accordance with the CONSORT statement of the updated guidelines for reporting randomised clinical trials. In our study, Pro-argin treatment revealed an immediate clinical reduction of 45.7% on SCASS, 56% on VAS used for mechanical stimuli, and 48.1% on VAS used for water jet stimuli in DH demonstrated in Tables 3, 5, and 6. J Evid Based Dent Pract. While your patients may have dentine hypersensitivity in common, their oral care needs will vary. Colgate Tandpasta Sensitive Instant Relief Whitening. Colgate Sensitive Pro-Relief Whitening - Colgate Professional The effectiveness of Colgate SENSITIVE INSTANT Relief toothpaste is built on its Pro-Argin technology with arginine and calcium from calcium carbonate. SHOULD A PATIENT CONTINUE USING Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE ONCE THE DENTINE SENSITIVITY HAS GONE? Colgate Sensitive Pro Relief Enamel Repair to strengthen weakened enamel and prevent enamel loss. Colgate Sensitive Pro-Relief Challenge Advert April 2012 3rd edition, Public Health England 2014. WHAT IS Colgate SENSITIVE INSTANT Relief Repair & Prevent? This toothpaste prevents sensitivity coming back by building a protective barrier that acts like . J Oral Sci. SEALS & REPAIRS: Pro-Argin technology helps to seal and repair the sensitive areas of teeth. Correspondence to J Clin Dent. When it begins to interfere with oral hygiene, it can also lead to poor oral health outcomes. Another study by Vu Pham and Anh Nguyen reported clinical improvement in DH by 38.9% on SCASS and 40.2% on VAS for mechanical stimulated DH immediately after application of Pro-argin [25]. Tandkrmen remineraliserar tandemaljen fr att ge bttre motstnd mot syraattacker. Colgate Sensitive Instant Relief Toothpaste 75ml | Dental Care - B&M Colgate Sensitive Toothpaste - Colgate Professional Colgate Sensitive Pro Relief Toothpaste, Original, 110g Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Felix J, Ouanounou A. Dentin hypersensitivity: etiology, diagnosis, and management. Treatment difference between FCPS, Pro-argin, and 8% strontium acetate was not statistically significant with a p>0.05 for sustained pain relief in DH. Can be used after the Colgate Sensitive Pro-Relief Desensitizing Paste. Google Scholar. Colgate Sensitive Pro-Relief Repair & Prevent Toothpaste Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. Patel VR, Shettar L, Thakur S, Gillam D, Kamala DN. However, we can conclude that both Pro-argin and strontium acetate-based dentifrices disrupt the pathophysiology of DH and are effective for immediate pain relief even one minute after application on sensitive teeth. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . Find products and services. There was statistically no significant difference in the baseline characteristics of gender, age, baseline mean scores of clinical parameters of SCASS, and VAS used for mechanical and water jet stimuli between the four treatment groups (p>0.05). Colgate Sensitive Pro-Relief Enamel Repair Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily Treatments provided to the patients were OTC dentifrices marketed with the claim of immediate pain relief in DH. It is clinically proven for instant and lasting Sensitivity relief* How does it work? In each study, a single fingertip application of Colgate Sensitive Pro Relief was found to provide significant immediate relief relative to the comparative toothpaste, a result that was maintained over the subsequent three days with twice-daily brushing with the same toothpaste. Amsterdam: Elsevier; 2015. p. 4576. The effect of the incorporation of fluoride into strontium containing bioactive glasses. Pro-Argin technology helps to seal and repair . 1). Read our disclaimer for details. 1 Nathoo et al. These dentifrices were extracted in a plain tube by the dental assistant from commercial packing and labelled with treatment codes to keep the principal investigator and participants blinded at the time of treatment assignment. Madurai: Best Dental Science College; 2020. J Dent. Mahmoodi B, Wood R, Cook R. Protection and acid resistivity of bioactive-glasses, arginine and calcium silicate. Colgate Toothpaste relieves the discomfort of tooth irritation by still addressing the root causes. J Clin Periodontol 42 (2015), 17, 4. Directions for Use: For instant relief, apply directly to the sensitive tooth with finger tip and massage gently for 1 minute, up to twice a day and for children 6-12 years once a week or less frequently. The Gum Health Physical is a new interactive digital tool you can use to quickly evaluate your patients in-office, and give them a personalized report they can use at home. 2008;29(8):1S-35S. Colgate Sensitive Pro Relief Whitening Toothpaste 75ml tube (Pack of 4) Instant and Lasting Relief Clinically Proven with Active Ingredients We have a surprise for you Find out all personalised promo codes that you are eligible for. ClinicalTrial.gov: National Library of Medicine (US). KruskalWallis test was used to compare treatment groups. The participants with self-reported sensitivity in teeth were clinically diagnosed with DH. *with direct application and daily brushing. Bae J-H, Kim Y-K, Myung S-K. Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysis. J Clin Dent 2009; 20 (Spec Iss): 123-130. 1Intervention for Group A denotes BioMin F. 2Intervention for Group B denotes Colgate Sensitive Pro relief. Colgate Sensitive Instant Relief Toothpaste 75ml (Pack of 4) Delivering better oral health - An Evidence-based toolkit for prevention. Table 6 presents the change in the mean scores on VAS against waterjet stimulus from baseline to subsequent efficacy interval within each treatment arm. Table 3 demonstrates the percent change in the mean scores of DH on SCASS relative to baseline within the group for each treatment arm. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (3.052.17) followed by strontium acetate (3.751.97) followed by FCPS (5.301.83) one minute after application. Explore the videos and articles found on this page to assist in better oral care. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. They don't. A 3-day randomised clinical study investigating the efficacy of two toothpastes, designed to occlude dentine tubules, for the treatment of dentine hypersensitivity. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. 2015;42(2):13141. Colgate Sensitive Pro-relief Instant Relief. Colgate Sensitive PRO-Relief - Colgate Professional For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. Thus, 128 participants completed the trial and were statistically analyzed for primary outcome measure of SCASS scores after lost to follow up (Fig. While FCPS in BioMin F can be the best possible treatment option for long-term management of DH in the form of OTC dentifrices. DH most commonly involves the facial surfaces of maxillary and mandibular permanent teeth. WHAT IS THE FLUORIDE CONTENT OF Colgate SENSITIVE INSTANT Relief Repair & Prevent TOOTHPASTE? Cunha-Cruz J, Wataha JC. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. Results of our study, together with the results of the previous studies, confirm the immediate clinical efficacy of Pro-argin for the relief of DH. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. Colgate Sensitive Pro-relief Instant Relief Matranga D, Matera F, Pizzo G. Evaluating the statistical methodology of randomized trials on dentin hypersensitivity management. Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate
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